自身免疫性溶血性贫血红细胞相关抗体检测及临床分析 |
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引用本文: | 龚辉,康春香,田文洪,何英,曾丽吟. 自身免疫性溶血性贫血红细胞相关抗体检测及临床分析[J]. 内科急危重症杂志, 2008, 14(4): 201-202 |
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作者姓名: | 龚辉 康春香 田文洪 何英 曾丽吟 |
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作者单位: | 深圳市福田人民医院,深圳,518033;深圳市福田人民医院,深圳,518033;深圳市福田人民医院,深圳,518033;深圳市福田人民医院,深圳,518033;深圳市福田人民医院,深圳,518033 |
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摘 要: | 目的:分析自身免疫性溶血性贫血(AIHA)患者血液中红细胞相关抗体(EAIg)免疫分型的临床意义。方法;采用流式细胞仪和抗人单克隆抗体检测24例AIHA患者的EAIg,并分析其亚型及其与临床的关系。结果:24例AIHA患者直接抗人球蛋白试验(Coombs)仅8例阳性,阴性16例,而FCM检测出其中13例EAIg阳性,类型分布以IgG+C3型多见,且贫血、溶血程度重,余依次为C3型、IgG型。结论:AIHA免疫分型可判定疾病的严重程度以及为临床治疗提供依据。
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关 键 词: | 自身免疫性溶血性贫血 流式细胞术 免疫分型 临床分析 |
Clinical Significance of Erythrocyte Associated Immunoglobulin Detection in Autoimmune Hemolytic Anemia Patients |
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Affiliation: | GONG Hui, KANG Chunxiang, Tian Wenhong, et al. (Futian People's Hospital, Shenzhen 518033, China) |
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Abstract: | Objective:To analyze the clinical significance of erythrocyte associated immunoglobulin (EAIg) and immunetyping in patients with autoimmune hemolytic anemia (AIHA). Methods: Flow cytometry and monoclonal antibodies were used to detect and analyze EAIg and their subsets. Results: Among 24 cases with AIHA, 8 were positive with direct Coombs' test, 16 were negative, but 13 cases were positive by FCM detection. Most of the AIHA showed IgG + C3 type, and with severe anemia and hemolysis. Conclusion: AIHA immunophenotype may suggest the severity of the disease and provide the evidence for clinical treatment. |
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Keywords: | Autoimmune hemolytic anemia Flow cytometry Immune typing Clinical analysis |
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