零回波时间动脉自旋标记及时间飞跃法MR血管成像诊断颅内动脉粥样硬化性狭窄

目的 观察零回波时间(ZTE)动脉自旋标记(ASL)MR血管成像(MRA)与时间飞跃法(TOF)MRA(TOF-MRA)诊断颅内动脉粥样硬化性狭窄(ICAS)的价值.方法 对25例临床疑诊脑卒中患者行TOF-MRA及ZTE ASL-MRA,并于2天内行DSA检查.采用26段法评价MRA所示颅内动脉图像质量及颅内大、中动...

MR angiography with zero time echo arterial spin labeling and time of flight methods for diagnosis of intracranial atherosclerotic stenosis

Objective To explore the value of zero time echo (ZTE) arterial spin labeling (ASL) MR angiography (MRA) and time of flight (TOF) MRA (TOF-MRA) in diagnosis of intracranial atherosclerotic stenosis (ICAS). Methods Twenty-five patients with clinical suspected stroke underwent TOF-MRA and ZTE ASL-MRA, and then received DSA within 2 days. The imaging quality, and the stenosis degrees of large and medium intracranial arterial segments were evaluated using 26-segment method. The image quality scores of MRA with 2 methods were compared, the consistency of MRA in evaluation on large and medium arteries stenosis were analyzed. Taken DSA results as the gold standards, the receiver operating characteristic (ROC) curves of MRA for diagnosing >50% stenosis were drawn, and the areas under the curve (AUC) were calculated and compared. Results Totally 625 segments in 25 patients were evaluated, including 273 large and medium-sized arterial segments and 352 small-sized arterial segments. No significant difference of imaging quality scores as found between ZTE ASL-MRA (32, 3]) and TOF-MRA (32, 3], Z=-0.57, P=0.57), while imaging quality of the large and medium-sized intracranial arteries on ZTE ASL-MRA (33, 3]) was higher on TOF-MRA (33, 3], Z=-2.10, P=0.04). ZTE ASL-MRA diagnosed stenosis in 271 segments of large and medium-sized arteries, the AUC (0.96, 95%CI0.93, 0.98]) of ZTE ASL-MRA for diagnosing >50% stenosis was higher than that of TOF-MRA (0.94, 95%CI0.90, 0.96], Z=2.78, P=0.01). Conclusion ZTE ASL-MRA was superior to TOF-MRA in imaging quality and diagnostic accuracy of large and medium-sized intracranial arteries stenosis.