Tumor necrosis factor-alpha G-308A gene polymorphism and coronary heart disease susceptibility: an updated meta-analysis |
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Authors: | Zhang Hai-Feng Xie Shuang-Lun Wang Jing-Feng Chen Yang-Xin Wang Yan Huang Tu-Cheng |
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Institution: | a Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Chinab Department of Cardiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China |
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Abstract: | PurposeSeveral studies have reported apparently conflicting findings for the effects of tumor necrosis factor-alpha (TNF-α) G-308A polymorphism on coronary heart disease (CHD) susceptibility. We undertook a systematic review and meta-analysis to investigate the association between this gene variant and CHD predisposition.MethodsWe systematically searched electronic databases (Medline, EMbase, Chinese BioMedical, BIOSIS, Global Health, PsycINFO, Allied and Complementary Medicine Database, Cochrane Library, HuGE Navigator, and British Nursing) for relevant studies published between 1947 and October, 2010. Summarized estimation of odds ratio (OR) and 95% confidence interval (CI) were calculated. Publication bias and heterogeneity among studies were explored.ResultsWe identified 24 studies providing data for 9 921 cases and 7 944 controls. Pooled analysis based on ORs adjusted by CHD risk factors showed that carrying the TNF-α gene A variant conferred a 1.5-fold increased risk of developing CHD (AG + AA vs. GG, OR = 1.50, 95% CI: 1.23-1.77) in Caucasian population. No significant association between the gene polymorphism and CHD risk could be found in other ethnic groups.ConclusionsIt is probable that carrying the A variant is associated with CHD risk in Caucasians but not in Asians, Indians, or Africans. Further studies are merited to assess the association in greater details, especially in Asians, Indians and Africans. |
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Keywords: | CHD coronary heart disease TNF-α tumor necrosis factor-alpha MHC major histocompatibility complex MI myocardial infarction HWE Hardy-Weinberg equilibrium PCR polymerase chain reaction RFLP restriction fragment length polymorphism CS coronary stenosis MAF minor allele frequency UA unstable angina SA stable angina SCD sudden cardiac death |
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