| 当归多糖及其分离组分对小鼠免疫功能的调节效应 |
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| 引用本文： | 夏雪雁,彭仁,王智勇.当归多糖及其分离组分对小鼠免疫功能的调节效应[J].武汉大学学报(医学版),2001,22(3):199-201,207. |
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| 作者姓名： | 夏雪雁 彭仁 王智勇 |
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| 作者单位： | 1. 武汉大学医学院药理学教研室
2. 武汉大学中南医院药剂科, |
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| 基金项目： | 湖北省教委资助项目,批准号 :130 2 90 |
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| 摘 要： | 目的 :研究当归总多糖 (ASP)及其分离组分对小鼠免疫功能的影响。方法 :选用正常及大剂量泼尼龙(PSL)所致免疫缺陷小鼠 ,观察ASP及其分离组分对补体C3含量、单核吞噬细胞功能、淋巴细胞转化、抗体形成功能及白细胞介素 2分泌功能的影响。结果 :ASP、ASP 1、ASP 3 2 5 0mg kg口服可提高正常小鼠补体C3含量及单核吞噬细胞功能。ASP 2 .0g kg可对抗PSL对细胞及体液免疫功能的抑制 ,体内、体外试验中均可使PSL抑制状态下小鼠脾淋巴细胞IL 2分泌功能改善。结论 :ASP具有广泛免疫调节效应
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| 关 键 词： | 当归 泼尼龙 淋巴细胞 白细胞介素2 |
The Effect of Angelica Sinensis Polysaccharide and Its Ingredients on Mice's Immunocompetence |
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| Xia Xue yan,Peng Ren xiu,Wang Zhi yong.The Effect of Angelica Sinensis Polysaccharide and Its Ingredients on Mice's Immunocompetence[J].Medical Journal of Wuhan University,2001,22(3):199-201,207. |
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| Authors: | Xia Xue yan Peng Ren xiu Wang Zhi yong |
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| Institution: | Xia Xue yan,Peng Ren xiu,Wang Zhi yong Department of Pharmacology,Medical College,Wuhan University,Wuhan 430071,China |
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| Abstract: | Objective :To study the effect of Angelica Sinensis Polysaccharide(ASP) and its ingredients on mice's immunocompetence. Method: The regulations of ASP and its ingredients on immunofunctions of normal and Prednisolone(PSL) induced immunodeficient mice was measured. Results: 250 mg/kg of ASP,ASP 1 and ASP 3 enhanced the alexin C3 content and the activity of mononucleophaga. When treated with 2.0 g/kg of ASP in vivo, the PSL induced inhibition of the cytoimmunity and humoral immunity was improved. ASP elevated the PSL induced decline of interleukin 2 (IL 2) production both in vivo and in vitro. Conclusion: The results suggest that ASP has an extensive effect on immunocompetence. |
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| Keywords: | angelica prednisolone lymphocytes interleukin 2 |
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