2 450 MHz微波辐射对大鼠海马长时程增强和脑组织脂褐素的影响

目的 探讨微波对学习记忆影响的作用机制。方法 对海马诱发电位的长时程增强(LTP)和脑脂褐素含量进行研究，用2450MHz微波理疗机为照射源，以大鼠为实验对象，分别采用在体海马诱发电位法和分光光度法。结果 10～25mW／cm^2强度范围内的连续微波，可以对弱条件刺激和强条件刺激引发的LTP的群峰电位(PS)峰值产生抑制作用，并存在强度一效应关系，在25mW／cm^2时脂褐素含量显著高于对照组和10mW／cm^2组(P＜0．05)。结论 10～25mW／cm^2强度范围内的2450MHz连续微波可以通过抑制海马LTP的生成和脑脂褐素含量增加，造成学习记忆损害。

Effects of 2 450 MHz Microwave on Long-term Potentiation of Hippocampus and Lipofuscin Contents in Rat Brain

Objective: To study the mechanism of the effects of microwave on learning and memory. Method: Long-term potentiation (LTP) of hippocampus induced potential and lipofuscin content in rat brain were studied. After irradiated by a 2450 MHz microwave, rats hippocampus induced potential in vivo was recorded and lipofuscin content in the brain was measured by fluorospectrophotometry. Result: Continuous microwave with 10-25 mW/cm2 intensity could inhibit the amplitude of the population spike (PS) of weak and strong stimuli induced LTP with an intensity-effect relationship. At 25 mW/cm2, lipofuscin content was significantly higher than control and 10 mW/cm2 group (P<0.05). Conclusion: Continuous microwave with 10-25 mW/cm2 intensity impairs learning and memory by restraining hippocampus LTP and brain lipofuscin content.