内皮脂酶与动脉粥样硬化

脂酶是一种水溶性酶,能水解甘油三酯、磷脂和胆固醇等一些非水溶性物质,对食物中脂肪的吸收、机体的能量平衡和血浆脂蛋白的代谢起着重要的作用。目前已发现多种具有上述功能的酶,这些酶不仅功能相似,而且氨基酸序列和基因结构相近,由于最初发现的酶主要以甘油三酯为底物,所以将这些酶统称为甘油三酯脂酶基因家族。内皮脂酶(endo-thelial lipase,EL)是唯一由内皮细胞合成的甘油三酯脂酶基因家族新成员,1999年Jaye等[1]和H irata等[2]两个小组分别独立克隆出了EL基因(endotheli-al lipase gene,LIPG)。EL与脂蛋白脂酶(lipoproteinlipase…

Endothelial lipase and atherosclerosis

Endothelial lipase(EL),a newly described member of the triglyceride lipase gene family,displays a previously phospholipase A1 activity,remodels high density lipoprotein(HDL) particle and reduced plasma HDL-cholesterol levels and the ability to joint to scavenger receptor class B type 1(SR-B1).Furthermore,EL also increases cellular apolipoprotein B-containing lipoprotein uptake,monocyte adhesion and infiltration into the tissues.Recently,some studies showed that the vascular atherosclerotic lesions were markedly attenuated in EL deficient mice compared with control,suggesting that EL may play a significant role in the formation of atherosclerotic lesions.