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Solid core column technology applied to HPLC-FD of paralytic shellfish toxins |
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| Authors: | Stacey L. DeGrasse Jeffrey A. DeGrasseKevin Reuter |
| Affiliation: | a US FDA, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Analytical Chemistry, Spectroscopy and Mass Spectrometry Branch, 5100 Paint Branch Parkway, HFS-707, College Park, MD 20740, USA b Joint Institute for Food Safety and Applied Nutrition, University of Maryland, College Park, MD 20742, USA |
| Abstract: | Pre-column oxidation liquid chromatography with fluorescence detection is a chemical method for analyzing paralytic shellfish toxins. In order to improve the sample throughput and efficiency of AOAC Method 2005.06, solid core particle column technology was evaluated. We demonstrate that supplanting the original fully porous particle column with a solid core particle column reduces sample analysis time from 15 to 5 min per sample and improves resolution. |
| Keywords: | Column HPLC Oxidation Paralytic shellfish toxins Saxitoxin Solid core Fused core |
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