Genetics of Sudden Cardiac Death |
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Authors: | Alon Barsheshet Andrew Brenyo Arthur J. Moss Ilan Goldenberg |
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Affiliation: | Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, NY 14642, USA. alon.barsheshet@heart.rochester.edu |
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Abstract: | Advances in genetic testing technology have led to a proliferation of new genetic tests and accelerated developments in the field of cardiovascular genetic medicine. These advances enhance presymptomatic diagnosis and can establish a definitive molecular diagnosis for symptomatic patients at risk for sudden cardiac death. Most importantly, genotype-phenotype correlations can add important information for predicting outcome and selecting treatment for patients with inherited arrhythmic disorders. This paper reviews the current data regarding genotype-phenotype correlations and the role of clinical genetic testing in diagnosis, prognosis, and management of inheritable disorders leading to sudden cardiac death. |
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