Reconstitution of the immune system after hematopoietic stem cell transplantation in humans |
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Authors: | Jan Storek Michelle Geddes Faisal Khan Bertrand Huard Claudine Helg Yves Chalandon Jakob Passweg Eddy Roosnek |
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Affiliation: | (1) Division of Hematology and Hematologic Malignancies, Department of Medicine, University of Calgary, Calgary, AB, Canada;(2) Division of Hematology, Department of Internal Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland;(3) Division of Hematology, HUG, 24 rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland |
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Abstract: | Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery. |
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Keywords: | Hematopoietic stem cell transplantation Immunity Immune deficiency Thymus Homeostasis |
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