A COMPARISON OF GLUTATHIONE REDUCTASE AND GLUTATHIONE PEROXIDASE ACTIVITES IN PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY ADULTS期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A COMPARISON OF GLUTATHIONE REDUCTASE AND GLUTATHIONE PEROXIDASE ACTIVITES IN PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY ADULTS

Authors:	BRAVEN, J. ANSARI, N. FIGGITT, D. P. FISHER, A. LUDERS, CHRISTINE HICKLING, P. WHITTAKER, MARY

Affiliation:	^*Department of Environmental Sciences, Plymouth Polytechnic Plymouth, Devon, UK Department of Rheumatology, Plymouth General Hospital Plymouth, Devon

Abstract:	A 30% increase in erythrocyte glutathione peroxidase (GP) activitywas found in patients with rheumatoid arthritis when comparedwith healthy controls (p = 0.001) whereas the increase in glutathionereductase (GR) was statistically insignificant. No correlationwas found between the activities of the enzymes and the erythrocytesedimentation rate (ESR). The enzyme activities were independentof age, sex, or type of drug treatment of the patients. A possibleinterpretation of the results is presented. KEY WORDS: Glutathione peroxidase, Glutathione reductase, Rheumatoid arthritis, Disease activity, Thiol, Peroxides

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