Dll4-Notch信号传递途径在血管发生中的作用

血管发生(angiogenesis)依赖多种促进血管发生因子和抑制血管发生因子之综合的交互作用所调控。血管内皮生长因子(VEGF)和Notch信号传递途径(Notch signaling pathway)参与此过程。之前研究已证明Notch信号传递途径在胚胎发育和肿瘤血管发生(tumour angiogenesis)中扮演重要的角色,而最近研究则发现在血管发育过程中Dll4-Notch信号传递途径扮演着前所未知的新角色,并阐明因Notch信号传递减少而引起血管缺陷之机制,从而揭示破坏肿瘤血管发生的新药物靶点。本文着重于介绍Notch信号传递途径的组成;Dll4-Notch在血管发生中的作用;以及Dll4-Notch对肿瘤治疗的意义。

Review of the role of D114-Notch signaling pathway in angiogenesis

Angiogenesis is regulated by complex interactions of multiple activators and inhibitors.Vascular endothelial growth factor(VEGF)and Notch signaling pathway are involved in such process.Recent studies have demonstrated that Notch signaling pathway plays a key role in the embryonic development and tumour angiogenesis,and identified the role of Dll4-Notch signaling during vascular development and the mechanism of the vascular defects which result from reduction of Notch signaling,thus Dll4-Notch became regarded as novel and important drug targets for disrupting tumour angiogenesis.This review emphasizes on introduction of the constitution of Notch signaling pathway,the role of Dll4-Notch in angiogenesis and the significance of Dll4-Notch for tumour therapy.