脑外伤患者血清兴奋性氨基酸水平与功能性恢复的分析

目的 探讨脑外伤患血清氨基酸水平与功能恢复的相关性。方法 采用高效液相色谱法（ＨＰＬＣ）检测了３０例脑外伤患外伤后２４ｈ内和６ｄ后的血甭中谷氨酸（ＧＬＵ）的水平，并在２４ｈ内采用格拉斯歌昏迷量表计分（ＧＣＳ０及２０ｄ后功能独立性９ＦＩＭ）的评定值进行相关性研究。结果 显示血清ＧＬＵ（２４ｈ）的水平和ＧＣＳ、ＦＩＭ得分呈良好的负相关，将２４ｙ测量的血清ＧＬＵ浓度与６ｄ血清ＧＬＵ浓度值比较，分为持

Excitatory amino acids and their relation to rehabilitation results of brain injury

Objective To study relation of levels of excitatory amino acids and rehabilitation results of the patients with brain injury. Methods High performance liquid chromatography was used to determine the glutamate concentration in the plasma of patients in 24 h and after 6 d with brain injury, and relative analysis with Glasgow Coma Scale (GCS) and Function Independent Measure (FIM) was made. Results The studies showed that the concentration of plasmatic glutamate was closely related to GCS and FIM (negative correlation with GCS and FIM,r 1=- 0.6566 ,P 1< 0.001 ; r 2=- 0.4839 ,P 2< 0.001 ).Conclusion The results suggest that excitatory amino acids may reflect the degree of patients with secondary cerebral damage and be as biochemical marks for evaluating the brain injury.