老年男性高尿酸血症与胰岛素抵抗及动脉粥样硬化相关性研究

目的 研究老年男性高尿酸血症与胰岛素抵抗及动脉粥样硬化的相关性.方法 对240例老年男性进行调查,按尿酸水平分为高尿酸组(HUA,n=58例)和正常尿酸组(对照组,n=182例),测量身高、体质量、收缩压、舒张压,并检测血尿酸、空腹血糖、甘油三酯(TG)、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇、空腹血浆胰岛素(FINS).测量颈动脉内膜中层厚度(IMT),同时计算胰岛素抵抗指数(HOMA-IR),分析临床资料及与IMT的相关性.结果 ①高尿酸血症检出率为24.2％;②高尿酸组TG、体质量指数(BMI)高于对照组,TG(2.28±1.41) mmol/L vs(1.49±0.87)mmol/L,BMI 25.98±2.58 vs 24.58±3.10,而HDL-C低于对照组(1.33±0.33)mmol/L vs(1.46±0.39)mmol/L(P ＜0.05或＜0.01);③高尿酸组FINS、HOMA-IR、IMT高于对照组(P＜0.05或＜0.01).结论 老年高尿酸血症人群的肥胖、代谢紊乱、胰岛素抵抗与IMT密切相关.

Relationship between insulin resistance and intima-media thickness in elderly male patients with hyperuricemia

Objective To investigate the relationship between insulin resistance and intima-media thickness in patients with hyperuricemia among the old males. Methods We divided 240 cases into two groups according to the serum uric acid level： hyperuricemia （ HUA, n = 58） and normal serum uric acid （control group, n = 182）, height, body mass, systolic blood pressure, diastolic blood pressure, serum uric acid, fasting plasma glucose（FPG）, triglyceride（TG）, total cholesterol, high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol and fasting insulin（FINS） were detected. IMT was examined,homeostasis rhode1 assessment of insulin resistance（HOMA-IR） was calculated at the same time. Results （1）The prevalence of hyperuricemia was 24.2± ;（2）In HUA group,the levels of TG, body mass index were signifieantly higher than those in control group TG（2.28 ± 1.41） m mol/L vs （1.49 ± 0.87） mmol/L,BMI 25.98±2.58 vs 24.58±3.10 ,and the level of HDL-C was significantly lower than that in control group （1.33±0.33） mmol/L vs （1.46±0.39） mmol/L（ P 〈0.05 or 〈0.01） （3）The levels of FINS,HOMA-IR and IMT were higher than those in control group （ P 〈0.05 or 〈0.01）. Conclusion The levels of obesity, metabolic disorder and insulin resistance are strongly associated with IMT in elderly patients with HUA.