| BCL-6和BCL-2蛋白在弥漫大B细胞淋巴瘤中的表达及其临床意义 |
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| 引用本文： | 孙冠星,曹祥山,李青. BCL-6和BCL-2蛋白在弥漫大B细胞淋巴瘤中的表达及其临床意义[J]. 临床荟萃, 2012, 27(8): 652-656 |
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| 作者姓名： | 孙冠星 曹祥山 李青 |
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| 作者单位： | 苏州大学附属第三医院常州市第一人民医院血液科,江苏常州,213003%苏州大学附属第三医院常州市第一人民医院病理科,江苏常州,213003 |
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| 摘 要： | 目的 探讨BCL-6和BCL-2蛋白的表达与弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)的临床特征及预后之间的关系.方法 应用免疫组织化学染色的方法检测BCL-6和BCL-2两种蛋白在46例DLBCL中的表达,并分析它们与DLBCL的临床特征及预后的关系.结果 BCL-6和BCL-2蛋白的阳性表达率分别为60.9％(28/46)和54.3％(25/46),BCL-6阳性组和BCL-2阴性组患者预后较好.结论 BCL-6和BCL-2的蛋白表达与DLBCL预后有一定相关性,可作为判断DLBCL预后的参考指标.
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| 关 键 词： | 高血压 心房颤动 左心房内径 心电描记术 |
Expression and clinical significance of BCL-6 and BCL-2 in diffuse large B-cell lymphoma |
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| SUN Guan-xing , CAO Xiang-shan , LI Qing. Expression and clinical significance of BCL-6 and BCL-2 in diffuse large B-cell lymphoma[J]. Clinical Focus, 2012, 27(8): 652-656 |
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| Authors: | SUN Guan-xing CAO Xiang-shan LI Qing |
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| Affiliation: | b a.Department of Hematology;b.Department of Pathology,the Third Affiliated Hospital of Soochow University,the First People＇s Hospital of Changzhou,Changzhou 213003,China |
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| Abstract: | Objective To investigate the relationship between BCL-6 and BCL-2 as well as the clinical features and prognosis of diffuse large B cell lymphoma（DLBCL）. Methods Immunohistochemistry stain was used to determine the expression of BCL-6 and BCL-2. Results Positive rates of BCL-6 and BCL-2 were 60.9%（28/46） and 54.3%（25/46）.BCL-6 positive and BCL-2 negative expression showed a trend to better overall survival（OS） and progression-free survival（PFS）. Conclusion The results suggest significant correlationship among BCL-6,BCL-2 and prognosis.Moreover,BCL-6 and BCL-2 may be the useful prognostic indicators in diffuse large B cell lymphoma. |
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| Keywords: | lymphoma large-cell diffuse proto-oncogene proteins c-bcl-6 proto-oncogene proteins c-bcl-2 prognosis |
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