顶空气相色谱法测定盐酸普鲁卡因中的残留溶剂

目的：建立盐酸普鲁卡因中乙醇、丙酮残留量的测定方法。方法：采用顶空气相色谱法，以水为溶解介质，色谱柱为DB一1301石英毛细管柱，柱温80℃，检测器为FID，检测器温度为250℃，进样口温度为150℃，结果：乙醇、丙酮的线性范围分别为0．025～2．0nag·ml-1（r=0．9999）和0．025—2．0mg·ml-1（r=0．9999）；平均回收率分别为99．6％（RSD=0．6％）和99．5％（RSO：1．1％）；定量限分别为4．79μg·ml-1和3．01μg·ml-1。结论：方法简单、准确，可用于盐酸普鲁卡因中乙醇和丙酮残留量的测定。

Determination of Residual Organic Solvents in Procaine Hydrochloride by Headspace Gas Chromatography

Objective： To establish a method for determination the residual organic solvents-alcohol and acetone in procaine hydro- chloirde. Method： The residual organic solvents were determined by headspace gas chroniatography on DB-1301 capillary column with FID detector,the samples were dissolved in water, the column temperature was 80℃, the detector temperature was 250 ~C, the inlet temperature was 150 ℃. Result： The linear ranges of alcohol and acetone were 0. 025-2. 0 mg.ml=1 （r =0. 999 9） and 0. 025-2.0 mg . ml - 1 （ r = 0. 999 9 ）, the average recoveries were 99. 6% （ RSD = 0.6% ） and 99. 5 % （ RSD = 1.1% ） respectively, the quantitative limits were 4. 79 μg.ml-1 and 3.01 μg.m1-1. Conclusion： The method is simple and accurate,it can be used for determination the re- sidual organic solvents in procaine hydrochloirde.