2010-2011年江苏省江阴地区临床分离病原菌耐药性调查

目的分析江阴地区医院患者常见病原菌及其耐药情况，为临床合理使用抗菌药物提供支持。方法对2010．9．1—2011．8．30住院患者分离菌株及其对抗菌药物的耐药情况进行回顾性分析。结果2010．9—2011．8江阴地区共分离病原菌10183株。其中真菌3162株，细菌7021株。革兰阴性菌5000株，占细菌总数71．21％，革兰阳性菌2021株，占细菌总数的28．79％；所有分离的病原菌中革兰阴性菌占前三位的为肺炎克雷伯氏菌，铜绿假单胞菌，大肠埃希氏菌，1137株肺炎克雷伯氏菌中检出ESBLs菌株99株（1．41％），878株大肠埃希氏菌中检出ESBLs菌株265株（30．18％），1130株铜绿假单胞菌中检出PDR—PA菌株132株（11．71％）；革兰阳性菌占前三位的是金黄色葡萄球菌，溶血葡萄球菌，表皮葡萄球菌，416株金黄色葡萄球菌中检出125株MRsA，检出率30．07％；对843株鲍曼不动杆菌中泛耐药的鲍曼不动杆菌（PDR—AB）检出率为28．27％。结论江阴地区出现多种耐药菌株．细菌耐药性不容忽视．加强地区性细菌耐药连续监测．对于指导临床合理使用抗生素和控制细菌耐药性非常重要．

Investigation on Antimicrobial Resistance of Pathogens Isolated From 2010 to 2011 in Jiangyin Region of Jiangsu Province

Objective To investigate on antimicrobial resistance of pathogens isolaged from 2010 to 2011 in Jiangyin region, so as to give reference for clinical rational application of anti-microorganism drugs. Methods To analyze the resistance of these strains isolated inpatients retrospectively from 2010.9.1 to 2011.8.30. Results A total of 10183 clinical strains were detected, including 3 162 fungal strains and 7 021 bacteria strains. Among the bacteria strains, 5 000 Gram-negative bacteria strains （occupying71.21%） and 2021 Gram-positive bacteria strains （occupying 28.79%）, in which the first three places were klebsiella pneumoniae, pseudomonas aeruginosa, escherichia coll. The detection rate of extended-spectrum beta-lactamases （ESBLs） to escherichia coli and klebsiella pneumoniae were 30.18% and 1.41%. The detection rate of PDR-PA to pseudomonas aeruginosa was 11.71%. Staphylococcus aurous, hemolysis staphylococcus and staphylococcus epidermidis ranked the first three of all Gram-positive bacteria strains. The detection rate of MrsA to staphylococcus aurous was 30.07%. The detection rate of PDR-AB to acinetobacter baumannii was 28.27%. Conclusions The antibiotic resistance of pathogenic bacteria is severely in Jiangyin region, it is essential to enhance the drug resistant surveillance so as to guide resonable clinical medicine.