细菌性脑膜炎、病毒性脑膜脑炎脑脊液sCD14的测定及其临床意义

目的 探讨细菌性脑膜炎、病毒性脑膜脑炎时脑脊液sCDl4的变化及其临床意义。方法 细菌性脑膜炎、病毒性脑膜脑炎患者入院24h内腰穿取脑脊液，用ELISA法测sCDl4的浓度，同时记录Glasgow评分，记录距离取脑脊液3d内的一次脑电图异常程度评分。分析脑脊液sCDl4与Glasgow评分和脑电图异常程度评分的关系。结果 细菌性脑膜炎、病毒性脑膜脑炎患者脑脊液sCDl4显著高于对照组，细菌性脑膜炎患者脑脊液sCDl4显著高于病毒性脑膜脑炎患者；脑脊液sCDl4浓度与脑0电图异常程度评分正相关，与Glasgow评分负相关。结论 细菌性脑膜炎、病毒性脑膜脑炎时脑脊液sCDl4显著升高，并且与脑功能损害程度正相关。

The measurement and clinical signification of sCD14 in bacterial meningitis and viral encephalomeningitis

Objective To evaluated the levels of soluble CD14(sCD14) in bacterial meningitis(BM) and viral encephalomeningitis(VEM),and to investigate its clinical signification. Methods CSF samples of BM and VEM were obtained in 24 hours after hospitalization. The levels of sCD14 were determined by ELISA(Enzyme Linked Zmmuno Sorbent Assay) and the Glasgow score was simultaneously recorded. We also noted the score of abnormality of EEG in three days after collecting CSF sample. Analyse the correlation of sCD14 concentration in CSF between Glasgow score and the abnormality of EEG. Results The sCD14 concentrations in CSF of BM and VEM were significantly higher than those in control group( P < 0.01 ),and those of BM were higher than those of VEM( P < 0.05 ). The sCD14 concentration in CSF was positively correlate with abnormality of EEG and was negatively correlate with Glassgow score. Conclusion The sCD14 concentration in CSF has high level in BM and VEM and is positively correlated with the loss of brain function.