| 电离辐射对胸腺细胞周期进程的影响 |
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| 引用本文： | 苏旭,张迎春,刘树铮.电离辐射对胸腺细胞周期进程的影响[J].吉林大学学报(医学版),1996(6). |
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| 作者姓名： | 苏旭 张迎春 刘树铮 |
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| 作者单位： | 白求恩医科大学卫生部放射生物实验室 |
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| 摘 要： | 本文采用流式细胞仪对小鼠Ｘ射线全身照射后胸腺细胞周期进程与Ｘ射线剂量效应关系进行了研究。４．０ＧｙＸ射线全身照射后４ｈ胸腺细胞便出现明显的ＤＮＡ合成抑制和Ｇ２阻滞，８ｈＧ２阻滞达到最高点。不同剂量全身照射的结果表明，低剂量（５０～１００ｍＧｙ）全身照射后胸腺细胞ＤＮＡ合成能力增强，而高剂量全身照射后则出现明显的ＤＮＡ合成抑制，Ｇ２阻滞和有丝分裂延迟。
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| 关 键 词： | 胸腺细胞 细胞周期 电离辐射 中图号 R81 |
Influences of ionizing radiation on the cell cycle progression of thymocytes in mice |
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| Su Xu,Zhang Yingchun,Liu Shuzheng.Influences of ionizing radiation on the cell cycle progression of thymocytes in mice[J].Journal of Jilin University: Med Ed,1996(6). |
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| Authors: | Su Xu Zhang Yingchun Liu Shuzheng |
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| Abstract: | The present study was designed to examine the cell cycle progression of mouse thymocytes and its dose effect relationship following whole body irradiation (WBI) using flow cytometry.It was found that after WBI with 4 Gy X rays DNA synthesis was suppressed with significant G 2 block beginning from 4 hours and reaching its peak at 8 hours.Dose effect study showed that DNA synthesis was stimulated with doses within 0.2 Gy,above which the opposite effect occurred together with G 2 block and cell division delay. |
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| Keywords: | ionizing radiation cell cycle thymocyte |
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