| 抗骨质疏松药雷尼酸锶的合成 |
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| 引用本文： | 丁翔宇,蒋晔,贾湘曼,刘丰华.抗骨质疏松药雷尼酸锶的合成[J].中国药学杂志,2008,43(11):874-876. |
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| 作者姓名： | 丁翔宇 蒋晔 贾湘曼 刘丰华 |
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| 作者单位： | 河北医科大学药学院,石家庄,050017 |
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| 摘 要： | 目的研究雷尼酸锶的化学合成。方法以枸橼酸为起始原料,经过脱羧、酯化、环合、烷基化、水解成盐等多步反应生成终产物雷尼酸锶。结果雷尼酸锶的结构经IR,1H-NMR,13C-NMR得到证实,总产率约为42.6%。结论本合成路线操作简单、成本低,适合工业化生产。
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| 关 键 词： | 雷尼酸锶 合成 骨质疏松 |
| 文章编号： | 1001-2494(2008)11-0874-03 |
| 收稿时间： | 2007-02-11; |
| 修稿时间： | 2007年2月11日 |
Synthesis of Strontium Ranelate, an Antiosteoporosis Drug |
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| DING Xiang-yu,JIANG Ye,JIA Xiang-man,LIU Feng-hua.Synthesis of Strontium Ranelate, an Antiosteoporosis Drug[J].Chinese Pharmaceutical Journal,2008,43(11):874-876. |
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| Authors: | DING Xiang-yu JIANG Ye JIA Xiang-man LIU Feng-hua |
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| Affiliation: | Institute of Pharmacy，Hebei Medical University，Shijiazhuang 050017，China |
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| Abstract: | OBJECTIVE To study the synthesis route of strontium ranelate,an antiosteoporosis drug.METHODS Strontium ranelate was synthesized from citric acid via decarboxylation,esterification,cyclization,alkylation,hydrolysis and salification.RESULTS The structure of strontium ranelate was confirmed by IR,1H-NMR,13C-NMR,the total yield was 42.6% approximately.CONCLUSION The synthesis route was simple,low cost and could be used in industry. |
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| Keywords: | strontium ranelate synthesis osteoporosis |
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