| 青蒿琥酯对IgA肾病模型大鼠血清IL-2、IL-6含量的影响 |
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| 引用本文： | 马云霞,栾森,马行一,曾燕,吴蔚桦,米绪华,秦伟.青蒿琥酯对IgA肾病模型大鼠血清IL-2、IL-6含量的影响[J].西部医学,2009,21(5):716-718. |
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| 作者姓名： | 马云霞 栾森 马行一 曾燕 吴蔚桦 米绪华 秦伟 |
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| 作者单位： | 四川大学华西医院肾脏内科,四川,成都,610041 |
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| 基金项目： | 四川省科技厅资助项目，四川省中医药管理局资助项目 |
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| 摘 要： | 目的观察青篙琥酯对IgA肾病模型大鼠血清IL-2、IL-6含量的影响。方法雄性SD大鼠50只，随机平均分为正常对照组、模型对照组、青蒿琥酯小剂量组、青蒿琥酯大剂量组和科素亚组，其中10只建立IgA肾病大鼠模型ELASIA法检测大鼠血清IL-2、IL-6含量。结果大鼠IgA肾病造模成功。青蒿琥酯可以明显抑制IgA肾病模型大鼠血清IL-2、IL-6含量。结论青蒿琥酯能够降低IgA肾病模型大鼠血清IL-2、IL-6含量，这可能是青蒿琥酯治疗IgA肾病的作用机制之一。
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| 关 键 词： | 青蒿琥酯 IgA肾病 IL-2 IL-6 |
The effect of artemisia on IL-2 and IL-6 in IgA nephropathy in rat |
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| Institution: | MA Yun-xia, LUAN Sen, MA Xing-yi,etal (West China Hospital, Sichuan University, Chengdu 610041, China) |
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| Abstract: | Objective To observe the effect of artemisia on IL-2 and IL-6 of IgA nephropathy in rat. Methods 50 male SD rats were randomly divided into 5 groups, including control group （C）, model group （M）, small does artemisia treated group （SDA）, high does artemisia treated group （HDA） and ARB treated group （ARB）. Interleukin 2 and interleukin 6 were detected with ELISA. Results Artemisia could obviously inhibit II.-2 and IL-6 of IgA nephropathy in rat. Conclusion Artemisia can degrade IL-2 and LL-6 in IgA nephropathy, which may be the mechanism of artemisia on IgA nephropathy. |
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| Keywords: | IL-2 IL-6 |
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