Protection of the Gastroduodenal Mucosa from the Effects of Diclofenac Sodium: Role of Highly Selective Vagotomy and Misoprostol |
| |
| Authors: | Athanasios D. Giannoukas Georgios Baltoyiannis Manolis Milonakis Dimitrios Nastos Lambros Papagikos Angelos M. Kappas Michalis Fatouros Constantinos Papadimitriou Diamantis Cassioumis |
| |
| Affiliation: | (1) Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR;(2) Department of Histopathology, School of Medicine, University of Ioannina, Ioannina, Greece, GR |
| |
| Abstract: | p = 0.474 and p = 0.62, respectively). Misoprostol alone also did not offer significant protection to the gastric or the duodenal mucosa ( p = 0.08 and p = 0.65, respectively). The combination of HSV plus misoprostol protected the gastric mucosa (group V, p = 0.007) but not the duodenal mucosa (group V, p = 0.08). Hence HSV or misoprostol alone offers no protection to the GDM from the effects of DS. The combination of HSV and misoprostol offers significant protection only to gastric mucosa. Enhancement of the mucosal defense mechanisms combined with strong reduction of gastric acidity may offer adequate protection to gastric mucosa from the effects of nonsteroidal antiinflammatory drugs. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
