Morbid obesity and functional status as predictors of surgical complication after renal transplantation |
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Authors: | Tara M Veasey James N Fleming Sara E Strout Ryan Miller Nicole A Pilch Holly B Meadows Caitlin R Mardis Benjamin A Mardis Sunil Shenvi John McGillicuddy Kenneth D Chavin Prabhakar Baliga David J Taber |
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Institution: | 1. Department of Pharmacy Services, Medical University of South Carolina, 280 Calhoun Street, MSC 132, Charleston, SC 29425, United States;2. Department of Surgery, Medical University of South Carolina, Clinical Sciences Building Suite 420, 96 Jonathan Lucas St., Charleston, SC 29425, United States;3. Department of Pharmacy, Ralph H. Johnson VAMC, 109 Bee Street, Charleston, SC 29401, United States |
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Abstract: | BackgroundThis study evaluated the impact of body mass index (BMI) and patient functional status on the risk for surgical complications after kidney transplant.MethodsThis retrospective cohort study of adult kidney transplant recipients grouped patients by baseline Karnofsky status (low function ≤ 70%) and further stratified by morbid obesity (BMI ≥ 35 kg/m2) to assess surgical complication risk.Results736 patients were included with surgical complications occurring in 25%. Logistic regression analysis with interaction terms demonstrated that morbid obesity and low functional status conditionally impact risk with an OR of 2.8 95% CI (1.1–7.3)]. Within the functional status cohort, BMI ≥35 kg/m2 was associated with increased risk of surgical complication, superficial wound infection, and DGF. Independent predictors for surgical complications included diabetes and morbid obesity with low functional status. There was no significant difference in graft loss or death across the cohorts.ConclusionsWhile neither morbid obesity nor poor functional status alone predicts increased complications, the combined presence is associated with significant increase in risk for surgical complications after renal transplantation. |
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Keywords: | Kidney Transplant Surgical Complication Function Obesity |
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