血管紧张素转换酶基因多态性与阻塞性睡眠呼吸暂停综合征

目的 探讨血管紧张素转换酶（ＡＣＥ）基因多态性与阻塞性睡眠呼吸暂停综合征（ＯＳＡＳ）之间的关系。方法 以ＡＣＥ基因内含子１６的一个２８７ｂｐ的Ａｌｕ顺序Ｉ／Ｄ（ｉｎｓｅｒｔｉｏｎ／ｄｅｌｅｔｉｏｎ）型为我希望标志，用聚合酶链反应（ＰＣＲ）扩增基因片段，对５０例ＯＳＡＳ患和５０名正常人ＡＣＥ基因多态性的分布进行了观察，并结合了观察，并结合临床特点和多导睡眠监测结果进行了分析。结果 发现在中国汉族正

Angiotension I converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome

OBJECTIVE: To investigate the relationship of an insertion/deletion (I/D) polymorphism of the angiotension-converting enzyme (ACE) gene to obstructive sleep apnea syndrome (OSAS). METHOD: Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers were flanking the polymorphic region in intron 16 of the ACE gene. RESULT: The distribution of the DD, ID, and II ACE genotypes was 16%, 52%, and 32% in the control subjects and 0%, 56%, and 44% in OSAS patients, respectively. The estimated frequencies of the insertion allele and the deletion allele were 58%, 42% in the control subjects and 72%, 28% in OSAS patients, respectively. The differences were statistically significant(P < 0.05). The OSAS patients with I/I genotype had significantly longer apnea time (P < 0.05), lower minimum SaO2(P < 0.05) and more severe AHI (P < 0.05) than did the OSAS patients with I/D genotype. CONCLUSION: These results indicate that the II genotype and I allele might be a risk factor for OSAS in Chinese.