中国成人硒需要量研究

目的 探讨使人体血浆硒蛋白P(SEPPI)达到饱和的硒摄入量,以评估硒需要量,为膳食硒参考摄入量DRIB的修订提供参考.方法 时98名低硒健康受试者(体重平均58kg)进行为期40w的双盲补硒实验.随机分为七组,补硒(以硒蛋氨酸形式)剂量分别为0、21、35、55、79、102和125 μg/d.定期检测血浆中谷胱甘肽...

STUDY ON THE SELENIUM REQUIREMENT FOR CHINESE

Objective To determine the intake of selenium needed to optimize human plasma selenoprotein P(SEPP1),thus allowing estimation of the selenium requirement.The value could be used as a reference for revising human selenium DRIs.Method A placebo-controlled double-blind study of selenium supplementation for 40 w was carried out in 98 healthy subjects(58kg bw) with low selenium status.Seven groups were assigned randomly with daily dose of 0,21,35,55,79,102,and 125 g selenium as selenomethionine.Plasma glutathione peroxidase(GPX3) activity,SEPP1 concentration,and selenium concentration as biomarkers were determined at intervals.A biomarker was considered optimized when its mean value was at the starting-point of plateau of dose-response curve.This corresponding intake could be assigned as selenium requirement.Results SEPP1 concentration was optimized at 40 w by selenium intake of 49 ?g/d.GPX3 activity was optimized by selenium intake of 35 ?g/d.Selenium concentration did not become saturated,thus it couldn't be used as biomarker to estimate the selenium requirement.Conclusion Plasma SEPP1 concentration is the best biomarker of selenium nutritional status and used for estimating selenium requirement.The selenium intake of 49 g/d with appropriate adjustments for body weight and individual variation can be used to estimate the human selenium requirement and as a reference for revising human selenium