Pacinian collagenoma: A distinct form of sclerotic fibroma |
| |
Authors: | Lucia Krivošíková Pavol Janega Jozef Babala Pavel Babál |
| |
Institution: | 1. Institute of Pathological Anatomy, Comenius University in Bratislava Faculty of Medicine, Bratislava, Slovakia;2. Institute of Pathological Anatomy, Comenius University in Bratislava Faculty of Medicine, Bratislava, Slovakia
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovakia;3. Department of Pediatric Surgery, Comenius University in Bratislava Faculty of Medicine, Bratislava, Slovakia |
| |
Abstract: | Sclerotic fibroma (storiform collagenoma) is a rare benign skin tumor. A solitary tumor, as well as multifocal lesions, are found either sporadically, or associated with Cowden syndrome. The tumor usually presents as clinically asymptomatic, slowly growing papule or nodule on the skin of the head, neck, and upper extremities. Microscopically the lesion is sharply demarcated, composed of hyalinized bands of collagen with low cellularity and a distinctive irregularly whorled or storiform pattern. We describe a case of a unique variant of this tumor in the scalp of a 33-year-old male. The tumor was microscopically composed of concentrically arranged collagen bundles with prevailing type III collagen, which resembled an enlarged Vater-Pacini corpuscle, with low density of CD34-positive and glucose transporter 1-negative spindle shaped cells. The specific microscopic appearance is suggestive of the term “Pacinian collagenoma” for this unique benign tumor. |
| |
Keywords: | CD34 GLUT-1 Pacinian collagenoma sclerotic fibroma type III collagen |
|
|