Vitamin D deficiency is common in kidney transplant recipients,but is not associated with infections after transplantation |
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| Authors: | Peter W. Schreiber Katharina Kusejko Heike A. Bischoff-Ferrari Katia Boggian Marco Bonani Christian van Delden Natalia Enriquez Thomas Fehr Christian Garzoni Hans H. Hirsch Cédric Hirzel Oriol Manuel Pascal Meylan Lanja Saleh Maja Weisser Nicolas J. Mueller the Swiss Transplant Cohort Study (STCS) |
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| Affiliation: | 1. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich and University Zurich, Zurich, Switzerland;2. Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland;3. Division of Infectious Diseases and Hospital Hygiene, Cantonal Hospital St. Gallen, St. Gallen, Switzerland;4. Division of Nephrology, University Hospital Zurich, Zurich, Switzerland;5. Service of Transplantation, Department of Surgery, University Hospitals Geneva and University of Geneva, Geneva, Switzerland;6. Department of Internal Medicine, Cantonal Hospital Graubünden, Chur, Switzerland;7. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Bern, Bern, Switzerland;8. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland;9. Infectious Diseases Service, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland Transplantation Center, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland;10. Infectious Diseases Service, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland;11. Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland |
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| Abstract: | The relevance of vitamin D for infections after kidney transplantation is poorly defined. 25-OH vitamin D (25-OHD) levels of 135 kidney transplant recipients, enrolled in the Swiss Transplant Cohort Study, were determined peri-transplant and 6 months post-transplant. Logistic regression was used to address the associations of 25-OHD and overall infections and bacterial infections, respectively. For the first 6 months post-transplant, 25-OHD peri-transplant, and for the second period (after 6 to 30 months post-transplant), 25-OHD at 6 months post-transplant was considered. Vitamin D deficiency was common peri-transplant and remained highly prevalent 6 months after transplantation despite frequent supplementation. Median 25-OHD levels increased from 12.0 ng/mL (IQR 5.3-19.5) peri-transplant to 16.5 ng/mL (IQR 10.6-22.6) 6 months post-transplant (P = .005). We did not detect a significant association between 25-OHD and overall infections (adjusted odds ratio (aOR) 1.05, 95% confidence interval (95%CI) 0.44-2.51; aOR 0.67, 95%CI 0.31-1.43) or bacterial infections (aOR 0.79, 95%CI 0.32-1.96; aOR 0.79, 95%CI 0.35-1.75) for the first and second period. To conclude, at both time points, vitamin D deficiency was observed in more than 50% of kidney recipients, albeit an increase in 25-OHD in the longitudinal course was observed. No significant association between 25-OHD and infections was detected. |
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| Keywords: | infections infectious disease medicine kidney transplantation vitamin D |
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