Vitamin D deficiency is common in kidney transplant recipients,but is not associated with infections after transplantation |
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| Authors: | Peter W Schreiber Katharina Kusejko Heike A Bischoff-Ferrari Katia Boggian Marco Bonani Christian van Delden Natalia Enriquez Thomas Fehr Christian Garzoni Hans H Hirsch Cédric Hirzel Oriol Manuel Pascal Meylan Lanja Saleh Maja Weisser Nicolas J Mueller the Swiss Transplant Cohort Study |
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| Institution: | 1. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich and University Zurich, Zurich, Switzerland;2. Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland;3. Division of Infectious Diseases and Hospital Hygiene, Cantonal Hospital St. Gallen, St. Gallen, Switzerland;4. Division of Nephrology, University Hospital Zurich, Zurich, Switzerland;5. Service of Transplantation, Department of Surgery, University Hospitals Geneva and University of Geneva, Geneva, Switzerland;6. Department of Internal Medicine, Cantonal Hospital Graubünden, Chur, Switzerland;7. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Bern, Bern, Switzerland;8. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland;9. Infectious Diseases Service, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland
Transplantation Center, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland;10. Infectious Diseases Service, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland;11. Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland |
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| Abstract: | The relevance of vitamin D for infections after kidney transplantation is poorly defined. 25-OH vitamin D (25-OHD) levels of 135 kidney transplant recipients, enrolled in the Swiss Transplant Cohort Study, were determined peri-transplant and 6 months post-transplant. Logistic regression was used to address the associations of 25-OHD and overall infections and bacterial infections, respectively. For the first 6 months post-transplant, 25-OHD peri-transplant, and for the second period (after 6 to 30 months post-transplant), 25-OHD at 6 months post-transplant was considered. Vitamin D deficiency was common peri-transplant and remained highly prevalent 6 months after transplantation despite frequent supplementation. Median 25-OHD levels increased from 12.0 ng/mL (IQR 5.3-19.5) peri-transplant to 16.5 ng/mL (IQR 10.6-22.6) 6 months post-transplant (P = .005). We did not detect a significant association between 25-OHD and overall infections (adjusted odds ratio (aOR) 1.05, 95% confidence interval (95%CI) 0.44-2.51; aOR 0.67, 95%CI 0.31-1.43) or bacterial infections (aOR 0.79, 95%CI 0.32-1.96; aOR 0.79, 95%CI 0.35-1.75) for the first and second period. To conclude, at both time points, vitamin D deficiency was observed in more than 50% of kidney recipients, albeit an increase in 25-OHD in the longitudinal course was observed. No significant association between 25-OHD and infections was detected. |
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| Keywords: | infections infectious disease medicine kidney transplantation vitamin D |
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