Maternal antibodies against paternal class I human leukocyte antigens are not associated with foetal and neonatal alloimmune thrombocytopenia |
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Authors: | Ulrich J. Sachs Sandra Wienzek-Lischka Yalin Duong Dan Qiu Wilko Hinrichs Nina Cooper Sentot Santoso Behnaz Bayat Gregor Bein |
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Affiliation: | 1. Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Germany German Center for Fetomaternal Incompatibility, Giessen, Germany;2. Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Germany;3. Institute for Medical Informatics, Justus-Liebig-University, Giessen, Germany;4. CSL Behring GmbH, Marburg, Germany |
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Abstract: | The causative role of maternal, anti-human leukocyte antigen (anti-HLA) class I antibodies in foetal and neonatal alloimmune thrombocytopenia (FNAIT) remains controversial. Furthermore, in FNAIT cases caused by anti-human platelet antigen-1a (anti-HPA-1a) antibodies, the possible additive effect of maternal anti-HLA class I antibodies on outcomes is unclear. Among 817 mother–father–neonate trios of suspected FNAIT, we assessed the possible association of maternal anti-HLA class I antibodies with neonatal platelet count, and the incidence of FNAIT caused by anti-HPA-1a antibodies. In 144 FNAIT cases caused by anti-HPA-1a antibodies, we investigated the possible association of maternal anti-HLA class I antibodies with neonatal platelet count, birth weight, and the incidence of intracranial haemorrhage (n = 16). Maternal anti-HLA class I antibodies were not associated with neonatal platelet count in suspected cases of FNAIT. There was no significant interaction between the presence of anti-HLA class I antibodies and anti-HPA-1a antibodies. In FNAIT cases caused by anti-HPA-1a antibodies, there was no association between the presence of anti-HLA class I antibodies and neonatal platelet count, birth weight, or occurrence of intracranial haemorrhage. This study’s findings do not support the concept that maternal anti-HLA class I antibodies represent a risk factor of FNAIT or disease severity. |
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Keywords: | pregnancy HLA class I antibodies foetal and neonatal alloimmune thrombocytopenia intracranial haemorrhage neonates |
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