|
|||||
|
|
Uptake of polygenic risk information among women at increased risk of breast cancer |
|
| Authors: | Tatiane Yanes Bettina Meiser Rajneesh Kaur Maatje Scheepers-Joynt Simone McInerny Shelby Taylor Kristine Barlow-Stewart Yoland Antill Lucinda Salmon Courtney Smyth Mary-Anne Young Paul A. James |
| Affiliation: | 1. Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia;2. Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, Victoria, Australia;3. Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia;4. Familial Cancer Clinic, Cabrini Health, Melbourne, Victoria, Australia;5. Clinical Genetics Service, Austin Hospital, Melbourne, Victoria, Australia;6. Familial Cancer Clinic, Monash Medical Centre, Melbourne, Victoria, Australia;7. Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, Victoria, Australia Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Sydney, Australia;8. Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, Victoria, Australia Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia |
| Abstract: | Polygenic risk scores (PRSs) are increasingly being implemented to assess breast cancer risk. This study aimed to assess and determine factors associated with uptake of PRS among women at increased risk of breast cancer for whom genetic testing to date had been uninformative. Participants were recruited from the Variants in Practice study from which breast cancer PRS had been calculated. Four hundred women were notified by letter of the availability of their PRS and invited to complete a self-administered survey comprising several validated scales. Considering non-participants, uptake of PRS was between 61.8% and 42.1%. Multivariate logistic regression identified that women were more likely to receive their PRS if they reported greater benefits (odds ratio [OR] = 1.17, P = .011) and fewer barriers to receiving their PRS (OR = 0.80, P = .007), had completed higher level education (OR = 3.32, P = .004), and did not have daughters (0.29, P = .006). Uptake of breast cancer PRS varied according to several testing- and patient-related factors. Knowledge of these factors will facilitate the implementation of polygenic testing in clinical practice and support informed decision making by patients. |
| Keywords: | breast cancer polygenic risk psychosocial single nucleotide polymorphism uptake |