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TCRs with segment TRAV9-2 or a CDR3 histidine are overrepresented among nickel-specific CD4+ T cells |
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| Authors: | Marina Aparicio-Soto Franziska Riedel Melanie Leddermann Petra Bacher Alexander Scheffold Heiner Kuhl Bernd Timmermann Dmitriy M. Chudakov Sonja Molin Margitta Worm Guido Heine Hermann-Josef Thierse Andreas Luch Katherina Siewert |
| Affiliation: | 1. Department of Chemical and Product Safety, German Federal Institute for Risk Assessment, Berlin, Germany;2. Institute of Immunology, Christian-Albrechts Universität zu Kiel and Universitätsklinik Schleswig-Holstein, Kiel, Germany Institute of Clinical Molecular Biology, Christian-Albrechts Universität zu Kiel, Kiel, Germany;3. Institute of Immunology, Christian-Albrechts Universität zu Kiel and Universitätsklinik Schleswig-Holstein, Kiel, Germany;4. Sequencing Core Facility, Max-Planck-Institute of Molecular Genetics, Berlin, Germany;5. Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia Center of Molecular Medicine, CEITEC, Masaryk University, Brno, Czech Republic;6. Division of Dermatology, Queen's University, Kingston, ON, Canada Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany;7. Division of Allergy and Immunology, Department of Dermatology, Venerology, and Allergy, Charité – Universitätsmedizin Berlin, Berlin, Germany |
| Abstract: | |
| Keywords: | CD154 upregulation assay CDR3 histidine human allergic contact dermatitis nickel-specific CD4+ T cells TCR α-chain segment TRAV9-2 |