|
|||||
|
|
The meninges enhance leukaemia survival in cerebral spinal fluid |
|
| Authors: | Patrick Basile Leslie M Jonart Maryam Ebadi Kimberly Johnson Morgan Kerfeld Peter M Gordon |
| Institution: | 1. Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA;2. Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA |
| Abstract: | Central nervous system (CNS) relapse is a common cause of treatment failure in patients with acute lymphoblastic leukaemia (ALL) despite current CNS-directed therapies that are also associated with significant short- and long-term toxicities. Herein, we showed that leukaemia cells exhibit decreased proliferation, elevated reactive oxygen species (ROS) and increased cell death in cerebral spinal fluid (CSF) both in vitro and in vivo. However, interactions between leukaemia and meningeal cells mitigated these adverse effects. This work expands our understanding of the pathophysiology of CNS leukaemia and suggests novel therapeutic approaches for more effectively targeting leukaemia cells in the CNS. |
| Keywords: | acute lymphpoblastic leukaemia central nervous system cerebral spinal fluid cell death cell adhesion |