氯胺酮麻醉对不同年龄烧伤患者术后认知功能的影响

目的研究氯胺酮麻醉后对不同年龄组烧伤患者术后认知功能的影响。方法采用MMSE评分的方法，通过对临床245例患者的临床调查研究了氯胺酮麻醉对不同年龄组A组（16—20岁）、B组（21～40岁）、C组（41～60岁）、D组（≥60岁）]烧伤患者认知功能的影响。结果术后第1天与其术前相比，A、B、C、D组的MMSE评分均下降（P〈0．05）；术后第7天与其术前相比，A、B、C组的MMSE评分没有明显变化（P〉0．05），而D组的MMSE评分下降（P〈0．05）。患者认知功能障碍发生率比较，A、B、C、D四组术后第1天发生率均较术后第7天为高（P〈0．05）；A、B、C、D四组两两比较，D组术后第1天、第7天发生率均较A、B、C组为高（P〈0．05），A、B、C组之间差异无统计学意义（P〉0．05）。结论氯胺酮麻醉后对不同年龄组的认知功能影响不同，认知功能障碍的发生可能与患者的年龄有关。

Effects of ketmine on postoperative cognitive dysfunction in different age groups of burn patients

Objective To study the effects of ketmine on postoperative cognitive dysfunction in differ- ent age groups of bum patients. Methods By MMSE, we investigate 245 examples of different age groups of burn patients A class（16 -20 age） ,B class（21 -40 age） .C class（41 -60 age） ,D class（ ≥60 age） ]in clinic, and research the effects of ketmine on postoperative cognitive dysfunction in those burn patiens. Results On the first day of postoperation MMSE＇ s scores of A.B.C and D classes are statistieaUy decreased as com- pared with before operation（P 〈0.05） ;On the seventh day MMSE＇ s scores of A.B and C classes were not hav- ing statistically significant（P 〉 0. 05 ）, but D class＇ s had statistically significant（ P 〈 0. 05 ）. As compared with occurrence rates of POCD in bum patients,A,B,C and D classes＇ were having statistically different between on the first day and the seventh day of postoperafion （ P 〈 0. 05 ）. On the first and the seventh day, D class＇ had statistically difference as compared with A.B and C classes（ P 〈0.05 ）. There were not statistically significant as compared with A,B and C classes （ P 〉 0. 05 ） Conclusion Effects of ketmine on postoperative cognitive dysfunction in different age groups of bum patients are different. Maybe the occurrence of POCD is coneemed with the age of patients.