文拉法辛与氟西汀治疗脑卒中后抑郁对照研究

目的比较文拉法辛与氟西汀治疗脑卒中后抑郁的临床疗效及安全性。方法将72例脑卒中后抑郁患者随机分为两组各36例,分别给予文拉法辛与氟西汀治疗8w,于治疗前及治疗后1w、2w、4w、8w末采用汉密顿抑郁量表、副反应量表评定临床疗效及不良反应。结果治疗8w末,研究组显效率75.0%、有效率94.4%,对照组分别为69.4%、88.9%,两组显效率、有效率比较均无显著性差异（χ^2=0.28、0.16,P均〉0.05）。汉密顿抑郁量表评分,治疗1w末起,两组均较治疗前有显著下降（P〈0.01）,且随治疗时间的延续呈持续性下降;同期两组间比较,治疗1w、2w末研究组较对照组下降显著（P〈0.01）,4w、8w末无显著性差异（P〉0.05）。两组不良反应均轻微。结论文拉法辛治疗脑卒中后抑郁疗效与氟西汀相当,但安全性、依从性,起效时间好于氟西汀。

A control study of venlafaxline vs. fluoxetine in the treatment of post-storke depression

Objective To compare the efficacy and side efffects of venlafaxline and fluoxetine in the treatment of post-storke depression.Methods 72 patients with post-storke depression were randomly divided into to two groups(each n=36)respectively received venlafaxline or fluoxetine for 8 weeks.Clinical efficacies were assessed with the Hamilton Depression Sale(HAMD)and side effects with the Treatment Emergent Symptom Scale(TESS)before treatment and the ends of week 1,2,4 and 8 treatment.Results At the end ef week 8,excellence and effectiveness rates were 75.0% and 94.4% in the research and 69.4% and 88.9% in the control group,which showed no significant differences(both P>0.05).Since the end of week 1,the HAMD scores of both groups lowered more significantly compared with pretreatment(P<0.01)and continously did along with therapy time lasting;at the ends of week 1 and 2,those lowered more significantly in the ersearch than in the control(P<0.01)and there were no significant differences at the ends of week 4 and 8 between two groups(P>0.05).The side effects of both groups were mild.Conclusion Venlafaxine has equivalent efficacy to fluoxetine,higher safety and better compliance,but the former takes effects quicker than the latter in the treatemnt of post-storke depression.