疏血通注射液联合阿司匹林治疗颈动脉粥样硬化的临床疗效及其对炎性细胞因子水平的影响

目的 探讨疏血通注射液联合阿司匹林治疗颈动脉粥样硬化(carotid atherosclerosis，CAS)的临床疗效及其对炎性细胞因子水平的影响。方法 60例CAS患者随机分为治疗组和对照组。对照组给予阿司匹林治疗，治疗组给予疏血通注射液联合阿司匹林治疗，治疗6个月后评价临床疗效。观察治疗前后血浆高敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平的变化。结果 治疗组临床疗效总有效率为 93.3%，显著高于对照组(63.3%)，具有统计学差异(P<0.05)；治疗后，治疗组hs-CRP，IL-6水平与治疗前和对照组比较明显降低(P<0.05)；治疗组血脂水平与治疗前和对照组比较明显降低(P<0.05)。结论 疏血通注射液联合阿司匹林治疗CAS临床疗效好，能降低炎性反应水平，值得临床推广应用。

Clinical Effects of Shuxuetong Injection Combined with Aspirin in Patients with Carotid Atherosclerosis and Effects on the Level of Inflammatory Cytokines

OBJECTIVE To investigate the clinical effects of Shuxuetong injection combined with aspirin in patients with carotid atherosclerosis(CAS) and effects on the level of inflammatory cytokines. METHODS Sixty cases with CAS patients were divided randomly into treatment group and control group. The patients in control group were given the aspirin therapy, and patients in treatment group were given the treatment of Shuxuetong injection combined with aspirin. The clinical efficacy was observed after treatment for 6 months. The plasma hs-CRP and IL-6 levels were detected. RESULTS The clinical total effective rate of treatment group was 93.3%, it was significantly higher than that of control group (63.3%)(P<0.05). After treatment, the hs-CRP and IL-6 level of treatment group were significantly lower than the prior-treatment and control group(P<0.05). The lipid level of the treatment group were significantly lower than the prior-treatment and control group(P<0.05).CONCLUSION The Shuxuetong injection combined with aspirin in patients with CAS has better clinical efficacy, can reduce the level of inflammatory cytokines and is worthy of clinical application.