自体骨髓单个核细胞经冠状动脉移植治疗扩张型心肌病1例报告

目的观察自体骨髓单个核细胞经冠状动脉移植治疗扩张型心肌病的可行性及临床效果。方法原发性扩张型心肌病1例,心功能NYHA Ⅳ级。抽取患者骨髓,用密度梯度法分离骨髓单个核细胞,经左、右冠状动脉分别直接注入经分离自体骨髓单个核细胞,术后观察及随访患者症状,心功能,心血管事件。结果术中和术后未见不良影响,无新发严重心律失常,心功能稳定。术后第三天患者因咽痛干咳伴发热6 小时,第五天出院,运动能力增加。结论自体骨髓单个核细胞经冠状动脉移植治疗扩张型心肌病技术简单, 安全,对患者创伤小,短期观察对患者未见不良影响,而运动能力增加,长期效果有待随访观察。

INTRACORONARY TRANSPLANTATION OF AUTOLOGOUS BONE MARROW MONONUCLEAR CELLS IN TREATING DILATED CARDIOMYOPATHY (ONE CASE REPORT)

Objective To observe the possibility and the clinical result of autologous intracoronary transplantation of bone marrow mononuclear cells (BMCs) in treating dilated cardiorayopathy. Methods A female patient with 45 year old was diagnosed with idiopathic dilated cardiomyopathy and in cardiac function NYHA VI. BMCs were isolated by Ficoll density gradient centrifugation from the marrow blood obtained from patient herself. After intracoronary transplantated with bone marrow mononuclear cells, the patient had been followed up to observe the symptoms, heart function, cardiovascular events. Result During or after BMCs transplantation, there was no any complications and negative effects with patient, no newly and seriously arrhythmia had been found, patient's heart function was stable. But in third day after transplantation, patient had a six hours fever followed a sore-throat and cough. In fifth day, patient had been discharged from hospital and with the capability of exercise increased. Conclusion The technique and performance of intracoronary transplantation of autologous bone marrow mononuclear cells in treating idiopathic dilated cardiomyopathy are simple, safe and feasible with capability of exercise increased, without significantly complications and severe cardiovascular events during a short period observation, however a long term follow-up should be performed.