退障凝胶与退障眼膏的体外释药比较

目的：比较退障凝胶与退障眼膏的体外释药特性,为研制退障凝胶提供依据。方法：以高效液相色谱法测定释放介质中大黄素、大黄酚的含量,并以此为指标,采用透析法研究退障凝胶与退障眼膏的体外释放特性。结果：退障凝胶中大黄素、大黄酚24 h的累积释放度分别为(98.3±1.1)%,(95.8±1.8)%,而眼膏剂仅为(10.62±0.7)%,(10.46±0.4)%,退障凝胶释药较眼膏剂快且完全,提高了生物利用度。结论：退障凝胶具有良好的缓释特性,作为眼部给药具有良好的开发前景。

Comparative Study on in vitro drug-release between Tuizhang ophthalmic gel and Tuizhang oculentum

Objective: To prepare Tuizhang gel to cure cataract, the characteristics of Tuizhang gel on the drug-releasing in vitro were evaluated by compared with Tuizhang oculentum. Method: The emodin and chrysophanol in the releasing mediator were determined by HPLC, and the drug releasing characteristics of Tuizhang gel and Tuizhang oculentum were studied by bag filter method. Result: The emodin and chrysophanol in Tuizhang gel released (98.3, 1.1)%, (95.8, 1.8)% within 24 hours, respectively, while those in Tuizhang oculentum released (10.62, 0.7)%, (10.46, 0.4)%, respectively. The emodin and chrysophanol in Tuizhang gel released more quickly and completely than in Tuizhang oculentum, so Tuizhang gel has enhanced the bioavailability. Conclusion: The Tuizhang gel is characterized by slow-release to some degree, and it shows a promising future on ophthalmic drug delivery.