| 急性淋巴细胞白血病细胞遗传学改变及其意义 |
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| 引用本文： | 吴海燕.急性淋巴细胞白血病细胞遗传学改变及其意义[J].医学综述,2010,16(23). |
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| 作者姓名： | 吴海燕 |
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| 摘 要： | 近年来,细胞遗传学在血液病中发挥越来越重要的作用。急性淋巴细胞白血病(ALL)是一类以常染色体结构或数量改变为特征的恶性疾病。ALL最重要的染色体结构改变包括t(9;22)(q34;q11)、t(12;21)(p13;q22)、t(1;19)(q23;p13),形成BCR-ABL、TEL-AML1、E2A-PBX1融合基因。染色体数量异常包括超二倍体、假二倍体、亚二倍体/近单倍体。现就ALL的细胞遗传学改变,细胞遗传学改变与发病机制,细胞遗传学改变与预后的关系以及细胞遗传学指导治疗进行综述。
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| 关 键 词： | 急性淋巴细胞白血病 细胞遗传学 发病机制 预后 治疗 |
Cytogenetic Changes in Acute Lymphoblastic Leukemia and Its Significance |
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| WU Hai-yan.Cytogenetic Changes in Acute Lymphoblastic Leukemia and Its Significance[J].Medical Recapitulate,2010,16(23). |
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| Authors: | WU Hai-yan |
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| Abstract: | Recently,cytogenetics play more and more important role in blood disease.Acute lymphoblastic leukemia(ALL) is a type of malignant disease which characterized by changes of chromosome structures and quantities.The most significant structural chromosomal changes of ALL include t(9;22)(q34;q11),t(12;21)(p13;q22),t(1;19)(q23;p13),forming fusion gene of BCR-ABL、TEL-AML1、E2A-PBX1.Numerical abnormalities include hyperdiploid,pseudo-diploid,hypodiploid/near haploid.This article focuses on the cytogenetic of ALL and the relationbetween cytogenetic changes of ALLand the pathogenesis and prognosis.Treatment guided by cytogenetic will also be disscussed. |
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| Keywords: | Acute lymphoblastic leukemia Cytogenetics Pathogenesis Prognosis Treatment |
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