Spectrophotometric quantitative determination of cilazapril and hydrochlorothiazide in tablets by chemometric methods |
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| Authors: | Dinç Erdal Baleanu Dumitru |
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| Institution: | 1. School of Studies in Chemistry, Jiwaji University, Gwalior 474011, India;2. Department of Chemistry, Howard University, Washington, DC 20059, USA;1. Laboratoire de Chimie des Matériaux, Université de Carthage, Faculté des Sciences de Bizerte, Zarzouna 7021, Tunisia;2. Laboratoire de Chimie Organométallique de Surface (LCOMS), Ecole Supérieure de Chimie Physique Electronique, Villeurbanne Cedex 69626, France;3. Department of Chemistry, University of Washington, BOX 351700, Seattle, WA 98195, USA;1. Department of Studies and Research in Chemistry, University College of Science, Tumkur University, Tumakuru 572 103, India;2. Department of Basic Sciences, School of Engineering and Technology, Jain University, Bangalore 562 112, India;3. Department of Studies in Physics, University of Mysore, Manasagangotri, Mysuru 570 006, India |
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| Abstract: | Four chemometric methods were applied to simultaneous determination of cilazapril and hydrochlorothiazide in tablets. Classical least-square (CLS), inverse least-square (ILS), principal component regression (PCR) and partial least-squares (PLS) methods do not need any priori graphical treatment of the overlapping spectra of two drugs in a mixture. For all chemometric calibrations a concentration set of the random mixture consisting of the two drugs in 0.1 M HCI and methanol (1:1) was prepared. The absorbance data in the UV-Vis spectra were measured for the 15 wavelength points (from 222 to 276 nm) in the spectral region 210-290 nm considering the intervals of deltalambda = 4 nm. The calibration of the investigated methods involves only absorbance and concentration data matrices. The developed calibrations were tested for the synthetic mixtures consisting of two drugs and using the Maple V software the chemometric calculations were performed. The results of the methods were compared each other as well as with HPLC method and a good agreement was found. |
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