| 输入供体血对延长大鼠移植胰腺功能存活的初步研究 |
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| 引用本文： | 孙治君,姚榛祥. 输入供体血对延长大鼠移植胰腺功能存活的初步研究[J]. 中国普外基础与临床杂志, 2001, 8(6): 364-366 |
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| 作者姓名： | 孙治君 姚榛祥 |
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| 作者单位： | 重庆医科大学临床学院器官移植研究室,重庆,400016 |
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| 摘 要： | 目的探索供体血输入同种大鼠对诱导胰腺移植耐受的可能性.方法用雄性Wistar大鼠作为实验的供受体,胰腺移植当天取供体大鼠全血1ml,注入糖尿病受体大鼠腹腔,辅以短期的硫唑嘌呤(Aza).结果移植胰腺功能存活时间为28～112天(平均64.2天),与单纯用硫唑嘌呤组(10.2天)或单纯输入供体血液组(9.8天)相比,移植胰腺功能存活时间显著延长(P<0.01).结论移植前短期使用免疫抑制剂以及移植当天输入供体血液,能延长大鼠移植胰腺功能存活时间.
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| 关 键 词： | 大鼠 供体血 胰腺移植 功能存活 |
| 文章编号： | 1007-9424(2001)06-0364-03 |
| 修稿时间： | 2000-09-02 |
THE INFLUENCES OF DONOR BLOOD INJECTION UPON PROLONGATION OF PANCREATIC ALLOGRAFTSURVIVAL IN RATS |
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| SUN Zhi-jun,YAO Zhen-xiang. Research Laboratory of Organ Transplantation,College of Clinical Medicine,Ch ongqing University of Medical Sciences,Chongqing. THE INFLUENCES OF DONOR BLOOD INJECTION UPON PROLONGATION OF PANCREATIC ALLOGRAFTSURVIVAL IN RATS[J]. Chinese Journal of Bases and Clinics In General Surgery, 2001, 8(6): 364-366 |
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| Authors: | SUN Zhi-jun YAO Zhen-xiang. Research Laboratory of Organ Transplantation College of Clinical Medicine Ch ongqing University of Medical Sciences Chongqing |
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| Affiliation: | SUN Zhi-jun,YAO Zhen-xiang. Research Laboratory of Organ Transplantation,College of Clinical Medicine,Ch ongqing University of Medical Sciences,Chongqing 400016 |
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| Abstract: | Objective To investigate the effe ct of donor blood transfusion on inducing pancreatic allograft tolerance in outbre d rat model. Methods Wistar male rats were used as blood an d pancreas donor, and diabetic recipients. One ml of donor blood injected into a bdomen of diabetic recipients on the day of transplantation and azathioprine gi ven 2 days pretransplant and continued for three days. Results Pancreas allograft survival was signifi cantly prolonged (28 to 112 days, media survival time 64.2 days). One ml of dono r blood alone injected into the abdomen and azathioprine given alone 2 days pret ransplant did not improve allograft survival (media survival time 9.8 vs 10.2 da ys). Conclusion Donor blood injected on the day of transplantation and a 3 days course of azathioprine started 2 days pretransplan t have strong synergism in inducing long term graft survival in this rat model. |
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| Keywords: | Rat Donor-specific transfus ion Pancreas transplant Graft survival |
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