小动物弥漫性脑损伤致伤装置的设计

目的临床上高发生率的弥漫性脑损伤多南角加速度和线加速度运动共同导致．目前相关研究中尚缺乏可产生此类复合加速运动的实验装置：笔者设计一种可同时产生角加速度和线加速度运动的实验装置。方法该装置为一个由高气流率气缸驱动的气动转换系统。动力气缸气流出入口经过扩大．且动力气缸高压腔发射前施加预压．而活塞运动经外设弹性塑胶垫缓冲后停止，实现了活塞产生瞬间超大线性加速度运动。借助于运动方式转换器的转换作用．实验装置将活塞直线运动转换为瞬间超大角加速度和线加速度复合运动．通过大鼠致伤实验验证该装置产生小动物脑弥漫性脑损伤的有效性。结果该装置产生了稳定的瞬间超大角加速度和线加速度复合运动．并成功复制了大鼠弥漫性脑损伤模型。结论该设计稳定、可控．使用方便．是一种适用于制作小动物弥漫性脑损伤模型的新型设备．

Experimental device for inducing diffuse brain injury in small animals

Objective To study the device for inducing both forms of accelerations which still scant in the current investigations, and provide combined linear and angular accelerations. Methods This device was a pneumatic conversion system, which dynamic driven by a high flow pneumatic cylinder. The power cylinder, the in/ex-porters of which was enlarged and prepressured, and its piston was eased at the end of its stroke with an external elastic sheet, the piston could be reached a high linear speed with great acceleration. With the conversion effects of the motion-form transformer, the linear acceleration of the slider was transformed to the head fixture＇s linear and angular accelerations. The efficiency induced diffuse brain injury（DBI）, in small animals was evaluated by imposing rat＇s head to this device. Results The device generated constant combined instant superlinear and angular accelerations and produced DBI in rats faithfully. Conclusion It is demonstrated that the device is well designed with convenient, controllable and stable nature. It is a feasible instrument for inducing DBI in small animals.