Aberrant cellular immune responses in humans infected persistently with parvovirus B19 |
| |
Authors: | Isa Adiba Norbeck Oscar Hirbod Taha Lundqvist Anders Kasprowicz Victoria Bowness Paul Klenerman Paul Broliden Kristina Tolfvenstam Thomas |
| |
Affiliation: | Institution for Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. adiba.isa@cmm.ki.se |
| |
Abstract: | A subset of parvovirus B19 (B19) infected patients retains the infection for years, as defined by detection of B19 DNA in bone marrow. Thus far, analysis of B19-specific humoral immune responses and viral genome variations has not revealed a mechanism for the absent viral clearance. In this study, ex-vivo cellular immune responses were assessed by enzyme linked immunospot assay mounted against the majority of the translated viral genome. Compared to seropositive healthy individuals, individuals with B19 persistence (2-8 years) showed larger number of responses to the structural proteins (P = 0.0022), whereas responses to the non-structural protein were of lower magnitude (P = 0.012). These observations provide the first findings of immunological discrepancies between individuals with B19 persistence and healthy individuals, findings that may reflect both failed immunity and antigenic exhaustion. |
| |
Keywords: | erythrovirus viral persistence cellular immunity T‐lymphocyte responses |
本文献已被 PubMed 等数据库收录! |
|