HER-1，HER-2在子宫内膜癌中的表达及与预后的关系

目的 评估HER-1，HER-2 在子宫内膜癌（endometrial cancer，EC） 中的表达及其与预后的关系。方法 分析解放军总医院2005 年1 月-2011 年3 月期间符合要求的子宫内膜癌组织中HER-1、HER-2 的表达与子宫内膜癌组织分级、浸润深度、分期及预后的关系。结果 HER-1 与组织分级、分期及浸润深度无关（P ＞ 0.05） ；阳性生存率为90.4%，阴性生存率为100%，其表达与预后呈负相关（P ＜ 0.05）。HER-2 表达与浸润深度、分化程度、分期无关（P ＞ 0.05） ；阳性生存率为98.6%，阴性生存率为95.96%，其表达与预后无关。结论 HER-1 与EC 的预后呈负相关，与浸润深度、组织分级、分期无关；HER-2 与浸润深度、组织分级、分期和预后无关。

Relation between HER-1 and HER-2 expression in endometrial carcinoma and its prognosis

Objective To study the HER-1 and HER-2 expression in endometrial cancer （EC） and its effect on its prognosis. Methods Clinical data about EC patients admitted to our hospital from January 2005 to March 2011 were retrospectively analyzed. Relation of HER-1 and HER-2 expression with EC pathology and prognosis was studied. Results HER-1 was not related with classification, staging and invasion depth of EC （P 〉 0.05）. The positive and negative survival rate of HER-1 was 90.4% and 100%, respectively. The HER-1 expression was negatively related with the prognosis of EC （P 〈 0.05）. The HER-2 expression was not related with the invasion depth, differentiation degree and staging of EC （P 〉 0.05）. The positive and negative survival rate of HER-2 was 98.6% and 95.96%, respectively. The HER-2 expression was not related with the prognosis of EC （P 〉 0.05）. Conclusion HER-1 is negatively related with the prognosis of EC and HER-2 is not related with invasion depth , classification and staging of EC.