| PHOTODYNAMIC AND PHOTOBIOLOGICAL ACTION OF SULFONATED PHTHALOCYANINES |
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| 引用本文： | 傅乃武,全兰萍,燕利学,黄磊. PHOTODYNAMIC AND PHOTOBIOLOGICAL ACTION OF SULFONATED PHTHALOCYANINES[J]. 中国癌症研究, 1992, 4(2): 1-5. DOI: 10.1007/BF02997500 |
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| 作者姓名： | 傅乃武 全兰萍 燕利学 黄磊 |
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| 作者单位： | Department of Pharmacology，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Department of Pharmacology，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Department of Pharmacology，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Department of Pharmacology，Cancer Institute，Chinese Academy of Medical Sciences，Beijing |
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| 摘 要： | Zinc sulfonated phthalocyanlne (ZnSPc) 10 - 20 mg/ kg plus light showed strong inhibition on mouse S-180 and RA795 lung carcinoma, Inhibition rate was 44.8% and 57. 4% respectively. Aluminum sulfonated phthalocyanlne (AlSPc) 20 mg/kg plus copper vapor laser or red light, tumor Inhibition rate of S- 180 was 62. 7% and 66. 8% respectively, AISPc 1.25 μg/ml caused severe photohe-molyses of red cells. At the dose of 10 μg/ml plus light, lipld peroxidation of red cell membrane was greatly enhanced. Acetylchollnesterase (AchEs) of red cell membrane inactivated, liver mitochondrial ATPase and microsontal G-6-Pase Inhibited. ZnSPc at the dose of 1. 25 μg/ml caused obvious photodamage on DNA of hepatoma cells.
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Photodynamic and photobiological action of sulfonated phthalocyanines |
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| Naiwu Fu,Lanping Quan,Lixue Yan,Lei Huang. Photodynamic and photobiological action of sulfonated phthalocyanines[J]. Chinese Journal of Cancer Research, 1992, 4(2): 1-5. DOI: 10.1007/BF02997500 |
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| Authors: | Naiwu Fu Lanping Quan Lixue Yan Lei Huang |
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| Affiliation: | 1. Department of Pharmacology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing
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| Abstract: | Zinc sulfonated phthalocyanine (ZnSPc) 10–20 mg/kg plus light showed strong inhibition on mouse S-180 and RA795 lung carcinoma, inhibition rate was 44.8% and 57.4% respectively. Aluminum sulfonated phthalocyanine (AlSPc) 20 mg/kg plus copper vapor laser or red light, tumor inhibition rate of S-180 was 62.7% and 66.8% respectively, AlSPc 1.25 µg/ml caused severe photohemolyses of red cells. At the dose of 10 µg/ml plus light, lipid peroxidation of red cell membrane was greatly enhanced. Acetylchollnesterase (AchEs) of red cell membrane inactivated, liver mitochondrial ATPase and microsomal G-6-Pase inhibited. ZnSPc at the dose of 1.25 µg/ml caused obvious photodamage on DNA of hepatoma cells. |
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