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19-oxygenated ent-kaurane diterpenoids from Isodon pharicus
Authors:Zhao Yong  Pu Jian-Xin  Huang Sheng-Xiong  Ding Li-Sheng  Li Li-Mei  Li Xian  Yang Li-Bin  Xiao Wei-Lie  Wu Ying-Li  Chen Guo-Qiang  Sun Han-Dong
Affiliation:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Abstract:Eight new 19-oxygenated ENT-kaurane diterpenoids were isolated from the aerial parts of Isodon pharicus. Their structures were determined by means of extensive spectroscopic techniques including interpretation of 1D and 2D?NMR spectra. Selected compounds were evaluated for their cytotoxicity against NB4, A549, PC-3, MCF-7, and SH-SY5Y cell lines.
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