| 生长停滞和DNA损伤诱导蛋白45α在肝再生及肝病中的研究进展 |
| |
| 引用本文： | 杨献光,李帅洪,和春翠,夏聪,朱琳,赵卫明,徐存拴. 生长停滞和DNA损伤诱导蛋白45α在肝再生及肝病中的研究进展[J]. 解剖学报, 2018, 49(2): 268-272. DOI: 10.16098/j.issn.0529-1356.2018.02.022 |
| |
| 作者姓名： | 杨献光 李帅洪 和春翠 夏聪 朱琳 赵卫明 徐存拴 |
| |
| 作者单位： | 1.河南师范大学生命科学学院，河南 新乡 453007; 2.河南省-科技部共建细胞分化国家重点实验室培育基地，河南 新乡 453007 |
| |
| 摘 要： | 生长停滞和DNA损伤诱导蛋白45α（GADD45α）是一种应激诱导蛋白，它可诱导Gadd45α基因的表达。GADD45α在再生肝及肝硬化、肝癌、肝衰竭等肝病中表达显著上调，与多种肝病发生发展及预后密切相关。GADD45α蛋白通过与其他蛋白相互作用，在调控细胞周期、维持基因组稳定、诱导细胞凋亡等方面发挥重要作用。以下我们综述了GADD45α与肝再生关系的研究进展,为进一步了解肝再生与肝脏疾病的发生机制以及治疗和预防肝病奠定基础。
|
| 关 键 词： | 肝再生 生长停滞和DNA损伤诱导蛋白45α DNA损伤修复 细胞增殖 |
| 收稿时间： | 2017-07-24 |
| 修稿时间： | 2017-10-23 |
Research progress of growth arrest and DNA damage inducible 45α in liver regeneration and liver diseases |
| |
| YANG Xian-guang LI Shuai-hong HE Chun-cui XIA Cong ZHU Lin ZHAO Wei-ming XU Cun-shuan. Research progress of growth arrest and DNA damage inducible 45α in liver regeneration and liver diseases[J]. Acta Anatomica Sinica, 2018, 49(2): 268-272. DOI: 10.16098/j.issn.0529-1356.2018.02.022 |
| |
| Authors: | YANG Xian-guang LI Shuai-hong HE Chun-cui XIA Cong ZHU Lin ZHAO Wei-ming XU Cun-shuan |
| |
| Affiliation: | 1.College of Life Science, He’nan Normal University, He’nan Xinniang 453007, China; 2.State Key Laboratory Cultivation Base for Cell Differentiation Regulation, He’nan Normal University, He’nan Xinxiang 453007, China |
| |
| Abstract: | The growth arrest and DNA damage inducible 45 alpha (GADD45α) is a stress-inducible protein. Variety of stress can induce the expression of growth arrest and DNA damage inducible 45alpha(Gadd45α) gene. Gadd45α has been found to be abundantly expressed in various liver diseases, and be closely related to the development and prognosis of liver cancer, liver fibrosis and fatty liver. GADD45α protein plays an important role in regulating cell cycle, maintaining genome stability, and inducing apoptosis by interacting with other proteins. This review summarizes the progress of liver regeneration and GADD45α, and could lay a foundation for further understanding of the mechanism of liver regeneration and liver diseases, and for the treatment and prevention of liver diseases. |
| |
| Keywords: | Liver regeneration Growth arrest and DNA damage inducible 45α Repair of DNA damage Cell proliferation |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《解剖学报》浏览原始摘要信息 |
|
点击此处可从《解剖学报》下载全文 |
