伊曲康唑短程疗法治疗角化型手癣2种方案比较

目的：讨价并比较伊曲康唑２种短程疗法治疗角化型手癣的临床疗效、真菌学疗效及安全性。方法：将４５例患分为１周疗法组和２周疗法组。１周疗法组给予伊曲康唑２００ｍｇＢｉｄ，服用７ｄ；２周疗法组给予伊曲康唑２００ｍｇＱｄ，服用１４ｄ。在服药前及停药后第２周及第４周进行临床症状和体征观察及真菌学镜检及培养。在服药前及停药第４周时进行肝功能检查。以停药第４周时的结果作为观察疗效的标准。结果：１周疗法组在停药第４周时的临床痊愈率为８２．６％，总有效率为９５．６％，真菌学治愈率为９５．６％。２周疗法组在停药第４周时的临床痊愈率为８１．８％，总有效率为９０．９％，真菌学治愈率为９５．４％。２组间差异不显（Ｐ〉０．０５）。２组各有２例患出现轻度副作用，均未见严重不良反应。结论：伊曲康唑的２种短程疗法治疗角化型手癣均有效，且具

SHORT TERM ITRACONAZOLE IN THE TREATMENT OF TINEA MANUS(HYPERKERATOSIS TYPE): COMPARISON OF TWO TREATMENT REGIMES

Objective:To evaluate and compare the efficacy and safety of two dosages of short term itraconazole in the treatment of tinea manus(hyperkeratosis type).Methods:45 cases were divided into two groups.1 week group was given itraconazole 400 mg/d for 7 days.2 week group was given 200 mg/d for 14 days.Before and 2nd and 4th week after treatment,signs and symptoms were assessed clinically,and scales were taken for mycological assessments(microscopy and culture).Before and the 4th week after treatment,liver function was tested.The results of the 4th week after treatment were used as the criteria to evaluate the efficacy.The results were analysed by x 2 test.Results:In 1 week group,the clinical cure rate,total effective rate and mycological cure rate at the end of 4 th week after treatment were 82 6%,95 6% and 95 6%,respectively.The results of 2 week group were 81 6%,90 9% and 95 4%,respectively.There was no significant difference between the two groups( P >0 05).Mild adverse events were recorded in 2 patients in each group.No severe adverse reactions were observed.Conclusion:Itraconazole 400 mg/d given for 1 week and 200 mg/d given for 2 week are both effective and safe regimes for the treatment of tinea manus(hyperkeratosis type).The advantages of 1 week regimen is that it has shorter course and can increase the patients compliance.