中药814对肺炎克雷伯杆菌诱发大鼠慢性阻塞性肺疾病的影响

为观察中药８１４ 对肺炎克雷伯杆菌诱发大鼠慢性阻塞性肺疾病（ＣＯＰＤ） 是否有影响， 用经鼻腔注入， 反复感染法建立大鼠ＣＯＰＤ模型。大鼠分为正常对照、感染、预防治疗、一般治疗和假治疗组。预防治疗组和一般治疗组大鼠分别于细菌感染前３ ｄ 和细菌感染后第４ 周开始用中药８１４灌胃治疗。结果表明， 两治疗组尤其是前者大鼠气管、细支气管和肺泡上皮细胞损伤轻微， 细支气管壁和肺间质炎症亦较感染组为轻。与感染组相比较，预防治疗组第８周起和一般治疗组第１６ 周大鼠单位面积内平均肺泡数增加 （Ｐ＜ ０．０５）， 第１６ 周， 预防治疗组大鼠血氧分压比感染组增高（Ｐ＜ ０．０５）， 血ＣＯ２ 分压降低 （Ｐ＜ ０．０５）， 两指标均接近正常水平。结果提示， 中药８１４ 对诱发大鼠ＣＯＰＤ有较明显干预作用

Treatment Effects of Chinese Herb 814 on Rat Chronic Obstructive Pulmonary Disease Induced by Klebsiella Pneumoniae

In order to observe the effectofChinese herb 814 on chronic obstructive pulm onary disease (COPD) induced by klebsiella pneum oniae, a rat COPD m odel w as established by repeatedly intranasal infecting. Wistar rats w ere random ly divided into 5 groups: Norm al control group (C), Infection group (K), preventive treatm ent group (KP), generaltreatm ent group (KG) and pseudotreatm entgroup (P) . The herb w as given to the anim als ofKPgroup through stom achalinjection 3 daysprior to infection and to the anim als ofKG group 4 w eeks after infection. The results w ere as follow s: The rat trache, bronchiole and alveoliepithelium in the tw o treatm ent groups, especially KPgroup only dem onstrated slight injury; The chronic inflam m ation in bronchiole w all and alveoli septa w as m ilder than in K group. The m ean alveolus num ber per unit area in KP group (from 8th w eek ) and KG group (at 16th w eek) w as significantly increased as com pared w ith that in the infection group. Both PaCO2 values and PaO2 values in KPgroup w ere returned to norm allevels (P> 0.05) at 16th w eek. Itsuggests that Chinese herb 814 has better interfering effects on developm ent of the ratCOPD.