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Detection of 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine by immunoaffinity/32P-post-labelling in liver and lung DNA of mice treated with ethylcarbamate (urethane) or its metabolites |
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| Authors: | Fernando, R.Charles Nair, Jegadeesan Barbin, Alain Miller, James A. Bartsch, Helmut |
| Affiliation: | German Cancer Research Center, Division of Toxicology and Cancer Risk Factors Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany 1International Agency for Research on Cancer, Unit of Environmental Carcinogens, 150, cours Albert Thomas F-69372 Lyon, France 2McArdle Laboratory for Cancer Research, University of Wisconsin Madison, WI 53706, USA |
| Abstract: | The capacity of the chemical carcinogen ethyl carbamate (EC,urethane) and its metabolites vinyl carbamate (VC) and vinylcarbamate epoxide (VCO) to form ethenobases was studied in liverand lung DNA of 12-day-old and adult CD-1, B6C3F1, C3H/HeJ andC57BL/6J mice. Following single and multiple doses of EC, VCor VCO, the formation of 1,N6-ethenodeoxyadenosine ( |
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