1 alpha(OH)D3 (ETALPHA) treatment and receptor studies in 16 patients with chronic and myeloproliferative disorders |
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Authors: | S B Wieslander B T Mortensen L Binderup N I Nissen |
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Affiliation: | Department of Internal Medicine, Finsen Institute, Copenhagen, Denmark. |
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Abstract: | 10 patients with CLL and 2 with CML were treated with gradually increasing doses of 1 alpha(OH)D3, up to 4 micrograms daily during 6 wk. 3 patients with preleukemia and 1 with myelofibrosis were treated with 2 micrograms daily of 1 alpha(OH)D3 for a prolonged period up to 17 wk. The treatment with 1 alpha (OH)D3 did not result in changes of disease parameters in any of the patients under study. Receptor studies for 1,25(OH)2D3 were performed in 8 CLL patients and revealed only 1 patient with increased specific receptor binding capacity. The maximum tolerable dose of 1 alpha(OH)D3 varied individually, but was in the range of 2-4 micrograms daily. |
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Keywords: | 1α(OH)D3 CLL CML myelofibrosis secondary preleukemia receptors for 1,25(OH)2D3 |
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