非甾体抗炎药相关性上消化道出血64例分析

目的探讨非甾体抗炎药（NSAIDs）相关性上消化道出血的临床特点。方法回顾性分析360例上消化道出血住院患者的临床资料，根据出血前10d内是否服用过NSAIDs将患者分为服药组和未服药组，对比分析两组患者的临床资料。结果360例上消化道出血患者中有64例（17．78％）服用过NSAIDs。两组比较，服药组患者年龄偏大、多有消化性溃疡和心脑血管病史（P〈0．05）；出血前消化道症状不明显（P〈0．01）；血红蛋白下降更多（P〈0．05）；胃溃疡和复合性溃疡、多发黏膜病损的情况在服药组更多见（P〈0．05）。但两组患者的性别、Hp阳性率差异无显著性（P〉0．05）。结论老年友具有消化性溃疡、心脑血管病史者更易发生NSAIDs相关性上消化道出血，无腹痛性消化道出血是其临床表现的特点。

Clinical analysis of non-steroidal anti-inflammatory drugs associated upper gastrointestinal bleeding

Objective] To evaluate the clinical characteristics of non-steroidal anti-inflammatory drugs (NSAIDs) associated upper gastrointestinal bleeding. Methods] Clinical datas of 360 patients with upper gastrointestinal bleeding were analysed retroversionally. Patients were divided into two groups based on whether consumed NSAIDs within 10 days previous to the onset of bleeding. Results] 64(17.78%) of 360 patients with upper gastrointestinal bleeding consumed NSAIDs. NSAIDs group were older than control group, more likely to have a history of peptic ulcer and cardiovascular disease(P <0.05). Gastrointestinal symptoms were not distinct before bleeding in NSAIDs group (P <0.01). Hemoglobin level was lower in NSAIDs group (P <0.05). There were more gastric ulcer ,complex ulcer and multiple mucous membrane impairment in NSAIDs group (P <0.05). But there was no significant difference in sex and Helicobacter pylori (HP) infection (P >0.05). Conclusion] The patients who are the aged or have a history of peptic ulcer or cardiovascular disease are more likely to have NSAIDs associated upper gastrointestinal bleeding. Upper gastrointestinal bleeding with no abdominal pain is the clinical characteristics of NSAIDs associated upper gastrointestinal bleeding.